Immune reactions and allergy in experimental anisakiasis.
10.3347/kjp.2006.44.4.271
- Author:
Sung Weon CHO
1
;
Haneul Nari LEE
Author Information
1. Department of Parasitology, Korea University College of Medicine, Seoul 136-705, Korea. csw0419@korea.ac.kr
- Publication Type:Research Support, Non-U.S. Gov't ; Review
- Keywords:
Anisakis simplex;
immune reaction;
IgE;
allergy;
ELISA;
rat
- MeSH:
Rats;
Mice;
Larva/immunology;
Immunoglobulin E/blood;
Hypersensitivity/*etiology/immunology;
Humans;
Enzyme-Linked Immunosorbent Assay;
Disease Models, Animal;
Antigens, Helminth/immunology;
Anisakis/growth & development/*immunology;
Anisakiasis/immunology;
Animals
- From:The Korean Journal of Parasitology
2006;44(4):271-283
- CountryRepublic of Korea
- Language:English
-
Abstract:
The third-stage larvae (L3) of the parasitic nematode, Anisakis simplex, have been implicated in the induction of hyperimmune allergic reactions in orally infected humans. In this work, we have conducted a review of an investigation into immune reactions occurring in animals experimentally infected with A. simplex L3. The patterns of serum antibody productions in the experimental animals against excretory-secretory products (ESP) of A. simplex L3 contributed to our current knowledge regarding specific humoral immune reactions in humans. In our review, we were able to determine that L3 infection of experimental animals may constitute a good model system for further exploration of immune mechanisms and allergy in anisakiasis of humans.
