Minor liver profile dysfunctions in Plasmodium vivax, P. malaria and P. ovale patients and normalization after treatment.
10.3347/kjp.2006.44.4.295
- Author:
Noppadon TANGPUKDEE
1
;
Vipa THANACHARTWET
;
Srivicha KRUDSOOD
;
Nutthanej LUPLERTLOP
;
Karnchana PORNPININWORAKIJ
;
Kobsiri CHALERMRUT
;
Sasikarn PHOKHAM
;
Shigeyuki KANO
;
Sornchai LOOAREESUWAN
;
Polrat WILAIRATANA
Author Information
1. Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand. tmpwl@mahidol,ac,th
- Publication Type:Original Article ; Clinical Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Plasmodium vivax;
Plasmodium malaria;
Plasmodium ovale;
malaria;
liver profile dysfunction;
artemisinin derivatives
- MeSH:
Treatment Outcome;
Sesquiterpenes/*therapeutic use;
Serum Albumin;
Plasmodium vivax/*drug effects/pathogenicity;
Plasmodium ovale/*drug effects/pathogenicity;
Plasmodium malariae/*drug effects/pathogenicity;
Middle Aged;
Male;
Malaria, Vivax/drug therapy/parasitology/physiopathology;
Malaria/*drug therapy/parasitology/physiopathology;
Liver Function Tests;
Liver/*physiopathology;
Humans;
Female;
Bilirubin/blood;
Artemisinins/*therapeutic use;
Anti-Infective Agents/therapeutic use;
Animals;
Alanine Transaminase/blood;
Adult;
Adolescent
- From:The Korean Journal of Parasitology
2006;44(4):295-302
- CountryRepublic of Korea
- Language:English
-
Abstract:
Liver function tests were performed in 61 vivax, 54 malariae and 15 ovale malaria patients who were admitted to Bangkok Hospital for Tropical Diseases between 2001 and 2004. The objective of the study was to evaluate changes in hepatic biochemical indices before and after treatment with artemisinin derivatives. On admission and prior to treatment, hepatic dysfunction was found among the 3 groups. Serum liver function tests and physical examinations were performed weekly during the 28-day follow-up period. Initially elevated serum bilirubin and diminished albumin returned to normal within 2 weeks of treatment. Serum alkaline phosphatase and aminotransferases returned to within normal limits within 3 weeks. We conclude that patients with Plasmodium vivax, P. malariae and P. ovale infections had slightly elevated serum bilirubin, aminotransferase and alkaline phosphatase levels, and hypoalbuminemia. These minor abnormalities returned to normal within a few weeks after treatment with therapies based on artemisinin derivatives.
