Two cases of alcohol-induced asthma.
- Author:
Seong Wook SOHN
1
;
Yoon Suk CHANG
;
Jae Young LEE
;
Jae Won JUNG
;
Sang Hoon KIM
;
Yoon Keun KIM
;
Sang Heon CHO
;
Kyung Up MIN
;
You Young KIM
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. drmin@snu.ac.kr
- Publication Type:Case Report
- Keywords:
alcohol;
asthma;
acetaldehyde;
genetic predisposition
- MeSH:
Acetaldehyde;
Adult;
Alcohol Drinking;
Alcoholic Beverages;
Asian Continental Ancestry Group;
Asthma*;
Drinking;
Dyspnea;
Eating;
Ethanol;
Female;
Genetic Predisposition to Disease;
Glucose;
Humans;
Korea;
Male;
Metabolism;
Middle Aged;
Respiratory Sounds
- From:Journal of Asthma, Allergy and Clinical Immunology
2001;21(6):1201-1205
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Alcohol-induced asthma is defined as exacerbation of asthmatic symptoms after drinking alcoholic beverages. This phenomenon is rare in Caucasians and is more specific to Asians. It has been observed among 50% of Japanese asthmatic patients and genetic predisposition in acetal-dehyde metabolism is thought to be a main factor in alcohol-induced asthma. Although the genetic predisposition of acetaldehyde metabolism in Koreans may be similar to the Japanese, alcohol-induced asthma has not been reported in Korea. We experienced two cases of alcohol-induced asthma which were confirmed by oral ethanol provocation test. In the first case, a 60-year-old male asthma patient presenting a recurrent episode of wheezing and dyspnea after alcohol consumption visited our clinic. After an oral challenge with 300ml of 10% ethanol solution dissolved in 5% glucose solution, dyspnea and wheezing episode were reproduced and 23% decrease in FEV1 compared to basal level was also shown at 20 minutes after ingestion. In the second case, a 32-year-old female asthma patient was presented with the same symptoms. After oral challenge, dyspnea and wheezing episode were reproduced and 30% decrease in FEV1 compared to basal level was shown at 60 minutes after ingestion. Short acting bronchodilator was applied and 21% increase in FEV1 resulted. They were instructed to avoid alcohol consumption with good results.
