A case of Sulfone syndrome hypersensitivity associated with dapsone.
- Author:
Hwan Won CHOI
1
;
In Kwan SONG
;
Eun A CHUNG
;
Dong Youb CHA
;
Mi Kyoung LIM
;
Dong Jib NA
;
Jong Sung CHOI
Author Information
1. Department of Internal Medicine, Sun General Hospital, Dae-Jeon, Korea. djna@sunhospital.com
- Publication Type:Case Report
- Keywords:
Sulfone syndrome;
Dapsone;
Hypersensitivity syndrome
- MeSH:
Anemia, Hemolytic;
Arthralgia;
Dapsone*;
Eosinophilia;
Exanthema;
Female;
Fever;
Hepatitis;
Hospitalization;
Humans;
Hypersensitivity*;
Lymphocytosis;
Middle Aged
- From:Journal of Asthma, Allergy and Clinical Immunology
2001;21(6):1206-1210
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sulfone hypersensitivity syndrome, which is characterized by fever, skin rash, hemolytic anemia, atypical lymphocytosis, and acute hepatic injury, is a potentially fatal variant of dapsone hypersensitivity. A 62-year-old woman with a history of arthralgia developed sulfone syndrome while receiving dapsone 100 mg/day for 20 days. Fever, malaise, prominent rashes, hepatitis, eosinophilia and hemolytic anemia developed and she which required hospitalization. The patient's symptoms reversed following discontinuation of dapsone and administration of steroid (0.5 mg/kg). A case of sulfone syndrome and a brief review of the literature were presented.
