Treatment of Herpes Simplex Ocular Disease with Ganciclovir Ophthalmic Gel.
- Author:
Ik Soo BYON
1
;
Ji Eun LEE
;
Jong Soo LEE
Author Information
1. Department of Ophthalmology, College of Medicine, Pusan National University, Pusan, Korea. jongsoo1@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
Acyclovir ointment;
Ganciclovir gel;
Herpes simplex ocular disease
- MeSH:
Acyclovir;
Blepharitis;
Burns;
Debridement;
Follow-Up Studies;
Ganciclovir*;
Herpes Simplex*;
Humans;
Keratitis;
Keratitis, Dendritic;
Keratitis, Herpetic;
Recurrence;
Sensation;
Visual Acuity;
Wounds and Injuries
- From:Journal of the Korean Ophthalmological Society
2005;46(1):164-170
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We report the therapeutic effect of ganciclovir gel instead of acyclovir ointment usually used in the case of herpes simplex superficial ocular disease such as herpetic dendritic keratitis and erosive blepharitis. METHODS: Three patients clinically diagnosed with herpes simplex dendritic keratitis and one as erosive blepharitis were treated with the topical ophthalmic gel of 0.15% ganciclovir three times a day for 2 to 4 weeks. Ocular complications and recurrence were evaluated under slit-lamp examination for the follow-up periods. RESULTS: Dendritic keratitis and erosive blepharitis were completely recovered with no recurrence during the 5 months follow-up. There is no respective comparison here. In one case of herpes simplex keratitis, the keratitis wound was repaired after debridement of corneal epithelial layer and application of ganciclovir gel. Complications including burning sensation and superficial punctate keratitis did not develop and visual acuity improved. CONCLUSIONS: Ganciclovir ophthalmic gel should be considered one of the effective therapeutic drugs for the herpes simplex ocular disease.
