Changes in Expressions of Endothelin-1, Microphthalmia Associated Transcription Factor, and Protease-activated Receptor-2 after Ultraviolet Irradiation.
- Author:
Whan Soo KIM
1
;
Kyu Min CHO
;
Moon Kyun CHO
;
Kyu Uang WHANG
Author Information
1. Department of Dermatology, College of Medicine, Soonchunhyang University, Seoul, Korea. akws711@hanmail.net
- Publication Type:Original Article
- Keywords:
Melanocyte;
Endothelin-1;
MITF;
Protease-activated receptor-2
- MeSH:
Cytokines;
Endothelin-1*;
Fibroblasts;
Humans;
Intercellular Signaling Peptides and Proteins;
Keratinocytes;
Male;
Melanins;
Melanocytes;
Microphthalmia-Associated Transcription Factor*;
Microphthalmos*;
Skin
- From:Korean Journal of Dermatology
2004;42(11):1419-1424
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: A number of cytokines, growth factors and inflammatory mediators made by keratinocytes, fibroblasts and potentially other cells in the skin were shown to augment melanin production and/or melanin transfer to keratinocytes. A lot of studies were done to investigate the mechanisms. But there was no studies about sequential relationship between the suggestive factors. OBJECT: To measure the changes in expressions of ET-1, MITF, and PAR-2 after UV exposure on skin in Korean. MATERIAL AND METHOD: We established an immunohistochemical staining protocol for specimens which were obtained from UV-irradiated skin in four healthy Korean males on the 2nd, 4th, 7th days after UV irradiation. RESULT: This study reveals the sequential relationship between ET-1, MITF, and PAR-2. ET-1 was increased at day 2 and decreased at day 4 and 7. MITF increased gradually day 2, day 4, and day 7. PAR-2 increased at day 4 and increased once more at day 7.
