A Case of Hair Change and Acneiform Eruption Induced by ZD1839 (Iressa(R)).
- Author:
Dong kee YU
1
;
Dae hun SUH
;
Jai Il YOUN
Author Information
1. Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. daehun@snu.ac.kr
- Publication Type:Case Report
- Keywords:
ZD1839 (Iressa(R));
Epidermal growth factor receptor;
Acneiform eruption;
Hair change
- MeSH:
Acneiform Eruptions*;
Hair*;
Kinetics;
Protein-Tyrosine Kinases;
Receptor, Epidermal Growth Factor;
Signal Transduction;
Skin
- From:Korean Journal of Dermatology
2004;42(11):1461-1465
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
ZD1839 (Iressa(R)) is a new anticancer agent, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that blocks signal transduction pathway implicated in the proliferation and survival of cancer cells and other host-dependent process promoting cancer growth. But this agent can induce cutaneous side effects including acneiform eruption, dry skin, and hair abnormality, which is related with the interruption of normal epidermal and hair follicular kinetics. We report a case of hair change and acneiform eruption induced by ZD1839 (Iressa(R)).
