Laser Doppler Estimated Cortical Hemodynamic Changes of Modified Fluid-Percussion Injury Model for Head Trauma Including Hyperosmolar Agent Infusion.
- Author:
Soo Han YOON
1
;
Ki Hong CHO
;
Kyung Gi CHO
;
Young Min AHN
;
Young Hwan AHN
Author Information
1. Department of Neurosurgery, Ajou University Hospital, School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Hemodynamics;
Fluid-percussion-injury model;
Laser doppler;
Controlled cortical injury model
- MeSH:
Administration, Intravenous;
Animals;
Craniocerebral Trauma*;
Head*;
Hemodynamics*;
Mannitol;
Models, Theoretical;
Rats
- From:Journal of Korean Neurosurgical Society
1996;25(10):1959-1963
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A study of cortical blood flow changes using laser Doppler was conducted in seven head injuried rats with subsequent intravenous administration of mannitol. Cortical blood flow after head trauma by the fluid-percussion model was decreased in 6 cases and initially increased and then decreased in 1 case. Cortical blood flows were dramatically increased about three to six times after intravenous administration of mannitol. These results suggest that the modified fluid-percussion cortical injury system is more stable and consistent than the old fluid-percussion injury model. It, therefore, seems applicable to be used as experimental models for head trauma.
