Association of MICA Polymorphism with HLA-B51 and Disease Severity in Korean Patients with Behcet's Disease.
10.3346/jkms.2002.17.3.366
- Author:
Sung Hwan PARK
1
;
Kyung Su PARK
;
Young Il SEO
;
Do June MIN
;
Wan Uk KIM
;
Tai Gyu KIM
;
Chul Soo CHO
;
Jee Won MOK
;
Kyung Sook PARK
;
Ho Youn KIM
Author Information
1. Center for Rheumatic Diseases, Kangnam St.Mary's Hospital, The Catholic University of Korea, Seoul, Korea. rheuma@cmc.cuk.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
MICA Polymorphism;
Behcet's Disease;
HLA-B51
- MeSH:
Adult;
Behcet Syndrome/*genetics;
Genetic Predisposition to Disease;
HLA-B Antigens/*genetics;
Histocompatibility Antigens Class I/*genetics;
Humans;
Korea;
Microsatellite Repeats;
Middle Aged;
Phenotype;
*Polymorphism, Genetic;
Severity of Illness Index
- From:Journal of Korean Medical Science
2002;17(3):366-370
- CountryRepublic of Korea
- Language:English
-
Abstract:
The HLA-B51 allele is known to be associated with Behcet's disease (BD) in many ethnic group. However, it has not yet been clarified whether the HLA-B51 gene itself is the pathogenic gene related to BD or whether it is some other gene in linkage disequlibrium with HLA-B51. Recently, the Triplet repeat (GCT/AGC) polymorphism in transmembrane region of the MHC class I chain-related A (MICA) gene was identified. To investigate the association of MICA with BD, we studied the MICA polymorphism in 108 Korean BD patients and 204 healthy controls in relation to the presence of HLA-B51 and clinical manifestations. The triplet repeat polymorphism was determined by polymerase chain reaction (PCR)-denaturing polyacrylamide gel electrophoresis (PAGE). The phenotype frequency of the MICA*A6 allele (relative risk, RR=2.15, p=0.002) and HLA-B51(RR=1.87, p=0.022) were significantly increased in the Korean patients with BD. A strong linkage disequilibrium was observed between the MICA*A6 and HLA-B51 in both the patients with BD and control subjects. Stratification analysis showed that MICA*A6 homozygosity was strongly associated with BD in the HLA-B51-negative population, and HLA-B51 was also associated with MICA*A6-negative population. In conclusion, MICA*A6 rather than HLA-B51 was strongly associated with Korean patients with BD, and the MICA*A6 allele is a useful susceptibility marker of BD, especially in the HLA-B5-negative
