Pyoderma Gangrenosum Associated with Idiopathic Myelofibrosis.
- Author:
Tae Jin CHOI
1
;
Yoon Hee KWON
;
Dou Hee YOON
;
Tae yoon KIM
;
Chung Won KIM
Author Information
1. Department of Dermatology, College of Medicine, The Catholic University Of Korea, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Pyoderma gangrenosum;
Idiopathic myelofibrosis
- MeSH:
Arthritis, Rheumatoid;
Biopsy;
Bone Marrow;
Colitis, Ulcerative;
Crohn Disease;
Diagnosis;
Female;
Fibroblasts;
Hematologic Diseases;
Hepatitis, Chronic;
Humans;
Leukemia;
Middle Aged;
Paraproteinemias;
Primary Myelofibrosis*;
Pyoderma Gangrenosum*;
Pyoderma*;
Reticulin;
Skin;
Thrombocytosis;
Ulcer
- From:Korean Journal of Dermatology
1997;35(4):781-785
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pyoderma gangrenosum is a rare, recurrent, painful and ulcerative skin disorder of unknown etiology, but is commonly associated with a variety of underlying systemic diseases of ulcerative colitis, rheumatoid arthritis, monoclonal gammopathies, Crohns disease, chronic active hepatitis and some hematologic diseases such as leukemia, thrombocythemia, dysglobulinemia and myeloma. We describe a 50 year-old woman who had pyoderma gangrenosum associated with idiopathic myelofibrosis. The findings of a bone marrow biopsy revealed proliferation of fibroblasts and a dense reticulin network, which were consistent with myelofibrosis. Steroid therapy resulted in a good response temporarily but, she died within a year after diagnosis. To our knowledge, our present case associated with idiopathic myelofibrosis is the first reported case in the Korean literature.
