The change of IL-2, IL-10 in cell culture supernatants of nasopharyngeal carcinoma (NPC) patients
- Author:
Binh Hoa Do
- Publication Type:Journal Article
- Keywords:
nasopharyngeal cancer
- MeSH:
Nasopharyngeal Neoplasms;
Nasopharyngeal Diseases;
Cell Culture Techniques;
Culture
- From:Journal of Medical Research
2000;14(1):13-17
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
In order to investigate the changes of some cytokines in NPC patients, we have made an measure of IL-2 and IL-10 in cell culture supernatants on 22 NPC patients, at II, III, IVa, IVb stage, positive anapathological test, compare with 12 healthy age-matched controls. The obtained results showed that: IL-2 production was significantly depressed in cell culture supernatants of NPC patients compare with control group. The production of IL-10 was increased in cell culture supernatants of NPC patients at late stages. It suggested that, IL-10 may be an prognostic factor in severe NPC patients and may prove valuable in selecting with NPC who are candidates for aggressive therapy
