Basal Cell Carcinoma and Actinic Keratosis Treated with Intralesional Injection of Recombinant Alpha-2 Interferon.
10.5021/ad.1995.7.2.116
- Author:
Sung In CHO
;
Yoon Whoa CHO
;
Chang Kwun HONG
;
Kye Yong SONG
;
Byung In RO
- Publication Type:Original Article
- Keywords:
Actinic keratosis;
Basal cell carcinoma;
Immunohistochemical stain;
Recombinant alpha-2 interferon
- MeSH:
Actins*;
Carcinoma, Basal Cell*;
Humans;
Injections, Intralesional*;
Interferons*;
Keratosis, Actinic*;
Skin;
T-Lymphocytes
- From:Annals of Dermatology
1995;7(2):116-120
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The effects of intralesional recombinant alpha-2 interferon(IFN) in the treatment of basal cell carcinoma(BCC) and actinic keratosis(AK) would be of value in selected patients. OBJECTIVE: Our purpose is to evaluate the differences of cellular immune reactions between the responded and the unresponded cases treated with IFN. METHODS: We treated five patients with BCC and two patients with AK with the intralesional injection of recombinant alpha-2 IFN. We performed immunohistochemical stainings with paraffin-embedded specimens from the pretreated and posttreated skin lesions. RESULTS: Four patients(three with BCC and one with AK) were healed and three patients showed improvement after treatment. In immunohistochemical stainings, there was an increased number of T cells in the dermal infiltrate of the responded cases but not in the unresponded cases. CONCLUSION: Intralesional IFN may induce T cell-mediated immune response at the site of the tumor by immune modulation.
