Enhanced Expression of Proliferating Cell Nuclear Antigen in Psoriatic Epidermis.
10.5021/ad.1995.7.2.169
- Author:
Sun Wook HWANG
- Publication Type:Original Article
- Keywords:
PCNA;
Psoriasis
- MeSH:
Cell Proliferation;
Epidermis*;
Humans;
Keratinocytes;
Proliferating Cell Nuclear Antigen*;
Psoriasis;
Skin
- From:Annals of Dermatology
1995;7(2):169-171
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The proliferating cell nuclear antigen(PCNA), one of the markers for proliferating cells, has been detected in solid human neoplasms. Psoriasis is a benign hyperproliferative disorder of the skin. OBJECTIVE: This study has been made to investigate if PCNA can be detected in the psoriatic epidermis. METHODS: Specimens from 10 patients with psoriasis were stained for PCNA using the one hour immunoalkaline phosphatase technique. RESULTS: The psoriatic epidermis showed positive nuclear staining in 20%-61% (mean, 45.7%) of keratinocytes. CONCLUSION: PCNA seems to be involved in the mechanism of increased epidermal cell proliferation in psoriatic lesions.
