Rapid-onset of severe tigecycline-induced coagulopathy in drug reaction with eosinophilia and systemic symptom syndrome.
- Author:
Yeong Jin JEONG
1
;
Byeongzu GHANH
;
Ji Wan LEE
;
Jinoh PARK
;
Tae Bum KIM
;
You Sook CHO
;
Hee Bom MOON
;
Hyouk Soo KWON
Author Information
- Publication Type:Case Report
- Keywords: DRESS syndrome; Tigecycline; Coagulopathy
- MeSH: Blood Cells; Drug Hypersensitivity Syndrome; Eosinophilia*; Exanthema; Fever; Humans; Hypersensitivity; Lymphatic Diseases; Partial Thromboplastin Time; Prothrombin Time
- From:Allergy, Asthma & Respiratory Disease 2016;4(1):74-78
- CountryRepublic of Korea
- Language:Korean
- Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome-also known as drug-induced hypersensitivity syndrome-is an uncommon disease entity that manifests as fever, skin rash, blood cell abnormalities, lymphadenopathy, and often coagulopathy. Tigecycline is an antibiotic that is selectively used to treat complicated intra-abdominal and soft-tissue infections. Recently, a few cases of tigecycline-induced coagulopathy have been reported. Herein, we report a case of tigecycline-induced coagulopathy in a patient with DRESS syndrome. Both prothrombin time and activated partial thromboplastin time were abruptly exceeded beyond 180 seconds on day 6 of tigecycline treatment and normalized after discontinuation of tigecycline.