Evaluation of thermally cross-linked superparamagnetic iron oxide nanoparticles for the changes of concentration and toxicity on tissues of Sprague-Dawley rats.
10.14405/kjvr.2014.54.4.245
- Author:
Jin Joo HUE
1
;
Hu Jang LEE
;
Sangyong JON
;
Sang Yoon NAM
;
Young Won YUN
;
Jong Soo KIM
;
Beom Jun LEE
Author Information
1. College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea. beomjun@cbu.ac.kr
- Publication Type:Original Article
- Keywords:
accumulation;
biodistribution;
rats;
thermally cross-linked superparamagnetic iron oxide nanoparticles;
toxicity
- MeSH:
Animals;
Body Weight;
Diagnosis;
Humans;
Indicators and Reagents;
Injections, Intravenous;
Interleukin-6;
Iron*;
Kidney;
Liver;
Male;
Malondialdehyde;
Nanoparticles*;
Rats;
Rats, Sprague-Dawley*;
Spleen;
Tumor Necrosis Factor-alpha;
Veins
- From:Korean Journal of Veterinary Research
2014;54(4):245-252
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was investigated the change of concentration and toxicity of thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) on tissues of Sprague-Dawley rats. TCL-SPION at the dose of 15 mg/kg body weight was intravenously injected into the tail vein of the male Sprague-Dawley rats. The fate of TCL-SPION in serum, urine and tissues was observed during 28 days. Serum iron level was maximal at 0.25 h post-injection and gradually declined thereafter. In addition, the sinusoids of liver and the red pulp area of spleen were mainly accumulated iron from 0.5 h to 28-day post-injection. In kidney, iron deposition was detected in the tubular area until 0.5 h after injection. Malondialdehyde concentration in the liver slightly increased with time and was not different with that at zero time. In the liver and spleen, TNF-alpha and IL-6 levels of TS treated with TCL-SPION were not different with those of the control during the experimental period. From the results, TCL-SPION could stay fairly long-time in certain tissues after intravenous injection without toxicity. The results indicated that TCL-SPION might be useful and safe as a contrast for the diagnosis of cancer or a carrier of therapeutic reagents to treat diseases.
