Ki-67 and VEGF as Possible Prognostic Factors in Radically-resected Ampulla of Vater Cancer.
- Author:
Kuk Jin KIM
1
;
Soon Won HONG
;
Joon Seong PARK
;
Ho Kyung HWANG
;
Jae Keun KIM
;
Kyung Sik KIM
;
Jin Sub CHOI
;
Dong Sup YOON
;
Woo Jung LEE
;
Hoon Sang CHI
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. yds6110@yuhs.ac
- Publication Type:Original Article
- Keywords:
Ampulla of Vater cancer;
Ki-67;
VEGF
- MeSH:
Ampulla of Vater;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
Prognosis;
Vascular Endothelial Growth Factor A
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2008;12(3):196-202
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Ampulla of Vater cancer has a more favorable prognosis and survival than other malignant periampullary tumors. The pathologic staging of ampulla of Vater carcinoma is a key determinant of the patient's prognosis. However, we have often encountered patients in whom the course of their disease differed substantially from what would be predicted based on their clinical staging, which highlights the need to consider additional predictive factors. We applied an immunohistochemical technique to examine the expression of Ki-67 and VEGF in radicallyresected ampulla of Vater carcinomas, and then compared the status of expression with several clinicopathologic factors. METHODS: Sixty-four patients who underwent curative resection for ampulla of Vater cancer between January 1992 and December 2006 at the Yonsei University College of Medicine were reviewed. The relationships between the expression of molecular markers and clinicopathologic factors were determined. RESULTS: There was no relationship between the clinicopathologic characteristics and the expression of molecular markers in patients with ampulla of Vater cancer. Among the clinicopathologic characteristics, lymph node metastasis was identified as an independent factor of survival after curative resection for ampulla of Vater carcinoma. CONCLUSION: Measurement of Ki-67 and VEGF in patients with ampulla of Vater carcinoma may have an important role in identifying the poor prognostic group.
