Acral Erythema and Hyperpigmentation Induced by Tegafur.
- Author:
Seog Jun HA
;
Sang Hee HAM
;
Young Min PARK
;
Sang Hyun CHO
;
Baik Kee CHO
- Publication Type:Original Article
- MeSH:
Breast Neoplasms;
Erythema*;
Female;
Fluorouracil;
Gastrointestinal Neoplasms;
Humans;
Hyperpigmentation*;
Keratoderma, Palmoplantar;
Tegafur*
- From:Korean Journal of Dermatology
1998;36(2):363-366
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil, used in the treatment of advanced gastrointestinal neoplasms. Mucocutaneous side reactions induced by this agent are rare and include photosensitivity of lichenoid and eczematous types, acral erythema, hyperpigmentation and palmoplantar keratoderma. However, to our knowledge, there has been no report of concurrent development of eruptions of two types in a patient. We describe a female patient with breast cancer, presented with combined features of acral erythema and hyperpigmentation due to oral tegafur.
