Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB.

Author: Tae Wook KYUNG ¹ ; Ji Eun LEE ; Hyun Hee SHIN ; Hye Seon CHOI
Author Information

1. Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Korea. hschoi@mail.ulsan.ac.kr
Publication Type:Original Article ; Research Support, Non-U.S. Gov't
Keywords: macrophages; NF-kappaB; osteoclasts; RANK ligand; reactive oxygen species; rutin; tumor necrosis factor alpha
MeSH: Animals; Mice; Mice, Inbred C57BL; NF-kappa B/*metabolism; Osteoclasts/*cytology/*drug effects; RANK Ligand/pharmacology; Reactive Oxygen Species/*metabolism; Rutin/*pharmacology; Tumor Necrosis Factor-alpha/*metabolism/pharmacology
From:Experimental & Molecular Medicine 2008;40(1):52-58
CountryRepublic of Korea
Language:English
Abstract: Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha Rutin also lowers NF-kappaB activation in response to RANKL.