Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB.
- Author:
Tae Wook KYUNG
1
;
Ji Eun LEE
;
Hyun Hee SHIN
;
Hye Seon CHOI
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: macrophages; NF-kappaB; osteoclasts; RANK ligand; reactive oxygen species; rutin; tumor necrosis factor alpha
- MeSH: Animals; Mice; Mice, Inbred C57BL; NF-kappa B/*metabolism; Osteoclasts/*cytology/*drug effects; RANK Ligand/pharmacology; Reactive Oxygen Species/*metabolism; Rutin/*pharmacology; Tumor Necrosis Factor-alpha/*metabolism/pharmacology
- From:Experimental & Molecular Medicine 2008;40(1):52-58
- CountryRepublic of Korea
- Language:English
- Abstract: Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha Rutin also lowers NF-kappaB activation in response to RANKL.