Tacrolimus-induced, Transplant-associated Thrombotic Microangiopathies after Lung Transplantation.
10.4285/jkstn.2016.30.2.94
- Author:
Ji Soo CHOI
1
;
Song Yee KIM
;
Jin Gu LEE
;
Soo Jeong KIM
;
Myung Jin SONG
;
Bo Ra YOON
;
Moo Hyun KIM
;
Moo Suk PARK
;
Hyo Chae PAIK
Author Information
1. Division of Pulmonology, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. dobie@yuhs.ac
- Publication Type:Case Report
- Keywords:
Thrombotic microangiopathies;
Lung transplantation;
Tacrolimus
- MeSH:
Aged;
Anemia, Hemolytic;
Diagnosis;
Dyspnea;
Hemorrhage;
Humans;
Idiopathic Pulmonary Fibrosis;
Lung Transplantation*;
Lung*;
Plasma Exchange;
Platelet Count;
Pneumonia;
Tacrolimus;
Thrombocytopenia;
Thrombotic Microangiopathies*;
Transplant Recipients
- From:The Journal of the Korean Society for Transplantation
2016;30(2):94-97
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of tacrolimus-induced transplant-associated thrombotic microangiopathies (TA-TMA) after lung transplantation. A 71-year-old man underwent lung transplantation secondary to idiopathic pulmonary fibrosis. After 4 months, he presented with abdominal discomfort and dyspnea, and was diagnosed with hemolytic anemia and thrombocytopenia. Tacrolimus was considered the cause of the TMA. Tacrolimus was stopped and several sessions of plasma exchange were performed immediately after diagnosis of TA-TMA. However, his platelet count did not normalize, gastrointestinal bleeding was recurrent, and severe pneumonia developed, following which he died. TA-TMA are rare but severe, life-threatening complications in lung transplant recipients. Therefore, the possibility of TA-TMA should be considered in posttransplant recipients.
