Chondroitin sulfate in Corneal Preaervation Media Assessed by monitoring the Transendothelial Electrical Potential Difference.
- Author:
Ha Bum LEE
1
;
Kyung Hwa LEE
;
Hyo Sub KIM
Author Information
1. Department of Ophthalmology, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
- Publication Type:In Vitro ; Original Article
- Keywords:
Chondroitin sulfate;
Corneal preservtion;
Transendothelial electrical potential difference
- MeSH:
Chondroitin Sulfates*;
Chondroitin*;
Cornea;
Glucose
- From:Journal of the Korean Ophthalmological Society
1989;30(6):893-897
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recently a great deal of attention has been focused on increasing corneal preservation time, and chondroitin sulfate in corneal preservation media can prolong corneal preservation time. So far evaluation of the effectiveness of this and some additives have been based on determining the state of the cornea at the end of the preservation period. We have accomplished this by monitoring in vitro the transendothelial electrical potential difference across deepithelialized rabbit cornea. We found that corneas stored in basal salt plus glucose containing chondroitin sulfate maintained higher transendothelial potential difference than corneas stored in the same solutions without chondroitin sulfate. The beneficial effects of chondroitin sulfate were opthimal at the 1% concentration.
