Survival and Prognostic Factors in Patients with Primary Pulmonary Hypertension.
- Author:
Kook Jin CHUN
1
;
Seong Ho KIM
;
Byung Jae AN
;
Sang Hyun KIM
;
Jae Kyung HA
;
Taek Jong HONG
;
Yung Woo SHIN
Author Information
1. Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Primary pulmonary hypertension;
Survival;
Prognosis
- MeSH:
Adult;
Age Distribution;
Female;
Hemodynamics/physiology;
Human;
Hypertension, Pulmonary/diagnosis/drug therapy/*mortality;
Incidence;
Korea/epidemiology;
Male;
Middle Age;
Prognosis;
Proportional Hazards Models;
Respiratory Function Tests;
Retrospective Studies;
Risk Factors;
Sex Distribution;
Survival Analysis
- From:The Korean Journal of Internal Medicine
2001;16(2):75-79
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: Primary pulmonary hypertension (PPH) that affects predominantly young and productive people is a progressive fatal disease of unknown cause. The objectives of this study were to characterize mortality in patients with PPH and to investigate the factors associated with their survival. METHODS: Thirteen patients with PPH were enrolled between 1988 and 1996 and followed-up through July 1999. Measurements at diagnosis included hemodynamic and pulmonary function variables in addition to information on demographic data and medical history. RESULTS: 1) The mean age of the patients with PPH enrolled into the study was 36.1+/-9.3 years with female predominance. 2) The estimated median survival was 3.4+/-0.6 years. 3) Decreased cardiac index was the only significant predictor of mortality (Cox proportional hazards model). CONCLUSION: Patients with PPH have a poor survival expectancy. In this limited study with a small number of patients, mortality is largely associated with decreased cardiac index.
