The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus.
- Author:
Sang Ah CHANG
1
;
Bong Yun CHA
;
Soon Jib YOO
;
Yoo Bae AHN
;
Ki Ho SONG
;
Je Ho HAN
;
Jong Min LEE
;
Hyun Sik SON
;
Kun Ho YOON
;
Moo IL KANG
;
Kwang Woo LEE
;
Ho Young SON
;
Sung Ku KANG
Author Information
1. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article ; Comparative Study
- Keywords:
Cilostazol;
Insulin resistance;
Streptozotocin-induced non-insulin dependent diabetic rat;
Euglycemic hyperinsulinemic clamp technique;
Glucose tolerance test
- MeSH:
Animal;
Animals, Newborn;
Blood Glucose/*drug effects;
Comparative Study;
Diabetes Mellitus, Non-Insulin-Dependent/chemically induced/*drug therapy;
Disease Models, Animal;
Glucose Tolerance Test;
*Insulin Resistance;
Male;
Probability;
Rats;
Rats, Wistar;
Reference Values;
Sensitivity and Specificity;
Streptozocin;
Tetrazoles/*pharmacology;
Vasodilator Agents/*pharmacology
- From:The Korean Journal of Internal Medicine
2001;16(2):87-92
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined. METHODS: About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats. RESULTS: In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats. CONCLUSION: These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.
