Severe Cutaneous Adverse Reaction.
10.3904/kjm.2014.87.6.665
- Author:
Min Suk YANG
1
;
Jae Woo JUNG
;
Hye Ryun KANG
Author Information
1. Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea. helenmed@snu.ac.kr
- Publication Type:Review
- Keywords:
Stevens Johnson syndrome, toxic epidermal necrolysis;
Drug hypersensitivity syndrome
- MeSH:
Cicatrix;
Drug Hypersensitivity Syndrome;
HLA Antigens;
Humans;
Pharmacogenetics;
Receptors, Antigen, T-Cell;
Stevens-Johnson Syndrome
- From:Korean Journal of Medicine
2014;87(6):665-674
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Severe adverse cutaneous reactions (SCARs) include Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). Although recent advances in pharmacogenomics have revealed the association between specific human leukocyte antigens (HLAs) and certain drug-induced SCARs, such associations were found in a limited number of drug-associated SCARs and are not sufficient to explain many other drug-related SCARs. After introducing research on the HLA-restricted T cell response, the role of the T cell receptor in drug binding was emphasized and a new concept called "pharmacological interactions of drug with immune receptors" has been conceptualized over recent decades. Currently, many international and domestic collaborative consortia have been formed and should enable the phenotypic standardization of SCARs at the earliest practicable time to provide valuable insights into its pathogenesis and to find an ideal method to prevent patients from developing SCARs.
