Clinical Outcomes between Living Related and Living Unrelated Kidney Transplantation in ABO-Incompatible Kidney Transplant Recipients.
10.3904/kjm.2014.87.6.698
- Author:
Wooyeong PARK
1
;
Seungyeup HAN
;
Eunah HWANG
;
Sungbae PARK
;
Uijun PARK
;
Hyungtae KIM
;
Wonhyun CHO
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. hansy@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Kidney transplantation;
Living-unrelated;
ABO-incompatible
- MeSH:
Follow-Up Studies;
Graft Rejection;
Graft Survival;
Humans;
Kaplan-Meier Estimate;
Kidney Failure, Chronic;
Kidney Transplantation*;
Kidney*;
Retrospective Studies;
Siblings;
Tissue Donors;
Transplantation*
- From:Korean Journal of Medicine
2014;87(6):698-704
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Kidney transplantation (KT) is the best treatment for end-stage renal disease patients. Although previous studies have demonstrated that the clinical outcome following living related (LR) KT is better than that following unrelated (LUR) KT in ABO-compatible KT recipients, recent studies showed no differences in clinical outcomes between the two treatments. In this study, we compared the clinical outcomes of LR and LUR KT in ABO-incompatible KT recipients. METHODS: From January 2011 to August 2013, 19 cases of ABO-incompatible KT were analyzed retrospectively. Eight kidneys (7 cases of parent-offspring and 1 case of siblings, Group 1) were donated from living-related donors and 11 (all spousal donors, Group 2) from living-unrelated donors. We investigated patient survival, graft survival, acute rejection, graft function, and complications. RESULTS: On Kaplan-Meier analysis, patient and graft survival during follow-up were 87.5% and 87.5% in Group 1; both were 100% in Group 2. Acute rejection, graft function, and medical and surgical complications were not significantly different between the two groups. CONCLUSIONS: The short-term clinical outcomes between LR and LUR KT in ABO-incompatible KT recipients were equivalent. Most domestic cases of LUR KT are from spousal donors and the spousal donor will be a major donor in ABO-incompatible KT patients.
