Annual Report on External Quality Assessment in Therapeutic Drug Monitoring in Korea (2002).
- Author:
Jeong Ho KIM
1
;
Woon Young YEO
;
Byung Kwang KIM
;
Young Soon JUNG
;
Soo Youn LEE
;
Sail CHUN
;
Dong Hoon SHIN
;
Kyung Eun SONG
;
Gye Cheol KWON
;
Kyung Ryul LEE
;
Jin Q KIM
Author Information
1. Therapeutic Drug Monitoring Subcommittee, The Korean Association of Quality Assurance for Clinical Loboratory, Seoul, Korea. jeongho@yumc.yonsei.ac.kr
- Publication Type:Review
- Keywords:
Quality assurance;
External quality assessment;
Therapeutic drug monitoring
- MeSH:
Acetaminophen;
Amikacin;
Amitriptyline;
Carbamazepine;
Cyclosporine;
Digoxin;
Drug Monitoring*;
Gentamicins;
Korea*;
Lithium;
Methotrexate;
Pathology, Clinical;
Phenobarbital;
Phenytoin;
Primidone;
Quinidine;
Tacrolimus;
Theophylline;
Tobramycin;
Valproic Acid;
Vancomycin
- From:Journal of Laboratory Medicine and Quality Assurance
2003;25(1):117-144
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Three trials of external quality assessment for Therapeutic Drug Monitoring (TDM) subcommittee of Korean Association of Quality Assurance for Clinical Pathology (KAQACP) were performed in 2002. Participating laboratories were 79 similar to the previous year. Response rates were 96.3% for 1st, 2nd, and third trials. In the first trial, 20 test items among 27 ones were responded from as least from one laboratory as follows: acetaminophen, amikacin, amitriptyline, carbamazepine, cyclosporine, digoxin, free phenytoin, gentamicin, lithium, methotrexate, phenobarbital, phenytoin, primidone, quinidine, salicylate, tacrolimus (FK-506), theophylline, tobramycin, valproic acid and vancomycin. In the second and third trial, the test items were same with those of 1st trial except the exclusion of quinidine. We included tacrolimus with a whole blood control material in addition to cyclosporine from the first trial. The most common test items were valproic acid, digoxin, phenytoin, carbamazepine, theophylline, and phenobarbital which were peformed in more than 77% of participating laboratories. The most widely used TDM analyzer was Abbott TDx/TDxFLx (56%), but its proportion were decreased slightly comparing with the previous years. In conclusion, we added tacrolimus from the year of TDM proficiency testing in 2002 and found grossly similar pattern comparing with those of previous years.