Effects of Prophylactic Antiemetic Combination of Dexamethasone and Ondansetron on Postoperative Nausea and Vomiting in High-risk Patients.
10.4097/kjae.2005.49.6.751
- Author:
Duck Hwan CHOI
1
;
Sang Hyun CHA
;
Eun Jin KIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. gi1519@hanmail.net
- Publication Type:Original Article
- Keywords:
dexamethasone;
ondansetron;
postoperative nausea and vomiting (PONV)
- MeSH:
Anesthesia, General;
Antiemetics;
Dexamethasone*;
Humans;
Incidence;
Ondansetron*;
Postoperative Nausea and Vomiting*;
Risk Reduction Behavior
- From:Korean Journal of Anesthesiology
2005;49(6):751-756
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: In the previous study, patients at high risk for postoperative nausea and vomiting (PONV) were identified by the Korean risk model. Consecutively, we investigated whether high-risk patients based on the Korean risk model could be managed with multiple prophylactic antiemetics. METHODS: Patients scheduled for elective surgery under general anesthesia were classified in two risk groups (first group: high risk group, second group: very high risk group) by using the Korean risk model. All patients received volatile general anesthesia and antiemetic combination of dexamethasone 5 mg (after induction) and ondansetron 4 mg (before end of surgery). We investigated the incidences of PONV in the postanesthetic care unit and at ward. RESULTS: Compared with the data from our previous study, the overall incidence of PONV decreased from 52.2% to 23.1% (P< or =0.001). The incidence decreased from 47.4% to 19.4% (P< or =0.001) in the high risk group and from 61.6% to 32.2% (P< or =0.001) in the very high risk group. The relative risk reduction did not differ between two groups (59.1%:47.7%). CONCLUSIONS: Antiemetic prophylactic with combination of dexamethasone and ondansetron was equally effective in reducing the occurrence of PONV in both group patients.
