A Case of Methomyl-induced Acute Allergic Tubulointerstitial Nephritis.
- Author:
Dong Hyun KIM
1
;
Sun Ae HAN
;
Hyung Nam KIM
;
Byung Chul SHIN
;
Yongjin PARK
Author Information
1. Department of Internal Medicine, Chosun University Hospital, Chosun University Medical School, Gwangju, Korea.
- Publication Type:Case Report
- Keywords:
Acute kidney injury;
Methomyl;
Nephritis;
Interstitial
- MeSH:
Acute Kidney Injury;
Adult;
Biopsy;
Education;
Eosinophils;
Humans;
Kidney;
Male;
Methomyl;
Nephritis;
Nephritis, Interstitial*;
Renal Dialysis;
Suicide
- From:Journal of the Korean Society of Emergency Medicine
2016;27(4):371-375
- CountryRepublic of Korea
- Language:English
-
Abstract:
Drug-induced interstitial nephritis is one of the causes of acute kidney injury. Although methomyl is widely used as an insecticide in many countries, methomyl-induced interstitial nephritis has not been reported thus far in the general population. We report a case of a 39-year-old male patient with acute allergic tubulointerstitial nephritis due to methomyl intoxication. He took methomyl 250 mL to commit suicide. He was treated with hemodialysis, but his renal function continued to deteriorate. Kidney biopsy demonstrated mononuclear cell and some eosinophils infiltration into the renal interstitium with tubular invasion. Immediate steroid pulse therapy, appropriate education, and conservative management resulted in gradual restoration of his renal function. This case suggests that methomyl may be a causative allergen inducing acute interstitial nephritis in some patients.
