Association of the Extent of Atrophic Gastritis With Specific Dyspeptic Symptoms.
- Author:
Sook Hee CHUNG
1
;
Kwang Jae LEE
;
Ja Yeon KIM
;
Seon Gyo IM
;
Eunkyung KIM
;
Min Jae YANG
;
Seo Hee RYU
Author Information
- Publication Type:Original Article
- Keywords: Atrophic gastritis; Dyspepsia; Epigastric pain syndrome; Postprandial distress syndrome
- MeSH: Adult; Atrophy; Dyspepsia; Female; Gastritis; Gastritis, Atrophic*; Humans; Male
- From:Journal of Neurogastroenterology and Motility 2015;21(4):528-536
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: It remains unclear whether atrophic gastritis can affect dyspeptic symptoms. We aimed to investigate whether the extent of atrophic gastritis is associated with specific dyspeptic symptoms. METHODS: Consecutive adults in a routine health-checkup program were enrolled in the study. The extent of atrophic gastritis was classified into 3 groups based on the Kimura-Takemoto criteria; the gastritis with no or little atrophy (group A: C0), the gastritis with atrophy mainly in the antrum (group B: C1 and C2), and the gastritis with atrophy in the large area of the corpus (group C: C3 and O). Upper gastrointestinal symptoms were categorized into "typical reflux symptoms," "epigastric pain syndrome (EPS)-related symptoms," and "postprandial distress syndrome (PDS)-related symptoms." RESULTS: A total of 1827 patients (1009 males, mean age 45.1 years) were included in the analysis. The subgroups of atrophic gastritis were as follows: group A (n = 1218, 66.7%), group B (n = 392, 21.4%), and group C (n = 217, 11.9%). Typical reflux, EPS-related, and PDS-related symptoms were present in 10.5%, 19.8%, and 16.2% of the subjects, respectively. PDS-related and EPS-related symptoms were significantly more prevalent in the group C of male patients and the group B of female patients, respectively, compared with other groups. PDS-related and EPS-related symptoms were independently associated with the group C in males (OR, 2.123; 95% CI, 1.090-4.136) and the group B in females (OR, 2.571; 95% CI, 1.319-5.025), respectively. CONCLUSIONS: The extent of atrophic gastritis appears to affect the generation of specific dyspeptic symptoms in a gender-dependent manner.
