Analysis of Pretreatment Prognostic Factors in Locally Advanced Carcinoma of the Uterine Cervix.
- Author:
Do Hoon OH
1
;
Sung Whan HA
;
Moo Song LEE
Author Information
1. Department of Therapeutic Radiology, Seoul National University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Cervix cancer;
Stage III & IV;
Prognostic factor;
Radiation therapy
- MeSH:
Cervix Uteri*;
Classification;
Disease-Free Survival;
Female;
Humans;
Multivariate Analysis;
Pregnancy;
Retrospective Studies;
Seoul;
Urinary Bladder;
Uterine Cervical Neoplasms
- From:Journal of the Korean Society for Therapeutic Radiology
1992;10(1):69-76
- CountryRepublic of Korea
- Language:English
-
Abstract:
To identify pretreatment prognostic factors in locally advanced carcinoma of the uterine cervix, retrospective analysis was undertaken of 154 patients treated with curative radiation therapy at Seoul National University Hospital, from March 1979 through December 1980. According to FIGO classification, eight patients were stage IIIA, 134 were stage IIIB, and 12 were stage IVA. Five year locoregional control rate was 58%, 51%, and 27% in stage IIIA, IIIB, and IVA, respectively. Five year disease free survival was 57%, 40%, and 25% for each stage respectively. Five year overall survival was 67%, 51%, and 33% in stage IIIA, IIIB, and IVA, respectively. In univariate analysis, fewer than or equal to four of pregnancies, initial hemoglobin of lower than 10 g%, and pelvic sidewall invasion on CT were associated with poor locoregional control. Number of pregnancies, initial hemoglobin level, obstructive uropathy on intavenous pyelography(IVP), pelvic lymph node(LN) status on CT, and pelvic sidewall Invasion on CT were significant factors in disease free survival. In terms of overall survival, pelvic sidewall invasion on CT and bladder invasion on CT were prognostically significant. In multivariate analysis, no factor was found to affect locoregional control and pelvic LN status was a sole significant factor affecting disease free survival. In terms of overall survival, the size of primary tumor was a significant prognosticator.
