The Effect of Sevoflurane Anesthesia on the Phase Relationship between Systolic Blood Pressure and Heart Rate.
10.4097/kjae.2007.53.5.571
- Author:
Young Kug KIM
1
;
Su Jin KANG
;
Seung Hye SUNG
;
Jae Moon CHOI
;
Ji Hyun CHIN
;
Gyu Sam HWANG
Author Information
1. Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. kyk@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
coherence;
phase;
sevoflurane anesthesia
- MeSH:
Anesthesia*;
Anesthesia, General;
Baroreflex;
Blood Pressure*;
Heart Rate*;
Heart*;
Humans
- From:Korean Journal of Anesthesiology
2007;53(5):571-576
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The phase relationship indicates the time delay between the input signal (systolic blood pressure, SBP) and output signal (R-R interval, RRI). In contrast to the awake state, little is known about the effects of general anesthesia on the phase shift. In the present study, we tested the hypothesis that sevoflurane anesthesia causes a phase change between the two signals. METHODS: We assessed changes in phase, coherence, and baroreflex sensitivity between SBP and RRI by the use of transfer function analysis in 50 ASA 1 patients during the awake state and during end-tidal 2% sevoflurane-50% N2O anesthesia. RESULTS: SBP and RRI decreased significantly during sevoflurane anesthesia (P < 0.001). The phase in the low frequency (LF) region remained unchanged, but the phase in the high frequency (HF) region changed significantly from -29.52 +/- 50.70 to 27.28 +/- 80.22 degrees during sevoflurane anesthesia (P < 0.001). Coherence and baroreflex sensitivity between the two signals in the LF and HF regions decreased significantly during sevoflurane anesthesia (P < 0.001, respectively). CONCLUSIONS: We found that in the HF region and not in the LF region, sevoflurane anesthesia provokes the shift of the SBP-RRI phase relationship, suggesting that this change is inconsistent with a vagally mediated response.
