The Effect of Ondansetron on the Emergence Agitation after Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy.
10.4097/kjae.2007.53.5.598
- Author:
Kun Moo LEE
1
;
Dong Hwa KANG
;
Sang Eun LEE
;
Young Hwan KIM
;
Se Hun LIM
;
Jeong Han LEE
;
Soon Ho CHEONG
;
Young Kyun CHOE
;
Young Jae KIM
;
Chee Mahn SHIN
Author Information
1. Department of Anesthesiology and Pain Medicine, Paik Hospital, College of Medicine, Inje University, Busan, Korea. aneslkm@inje.ac.kr
- Publication Type:Original Article
- Keywords:
emergence agitation;
ondansetron;
pediatric;
sevoflurane
- MeSH:
Anesthesia*;
Child;
Dihydroergotamine*;
Humans;
Incidence;
Ondansetron*;
Serotonin 5-HT3 Receptor Antagonists;
Tonsillectomy*
- From:Korean Journal of Anesthesiology
2007;53(5):598-601
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Emergence agitation is a common problem after sevoflurane anesthesia in children. Tropisetron, a 5-HT3 antagonist, significantly reduces the incidence of emergence agitation after sevoflurane anesthesia. This study evaluated the effect of ondansetron on emergence agitation after sevoflurane anesthesia in children undergoing a tonsillectomy. METHODS: Eighty children, aged 3-9 years (ASA physical status I) undergoing tonsillectomy, were randomly enrolled in this study. Group O received 0.1 mg/kg of ondansetron, and group S received 0.1 ml/kg of saline during the operation. Anesthesia was induced with 5 vol% sevoflurane and maintained with 2-2.5 vol% sevoflurane. The agitation score was recorded when they arrived at the postanesthesia care unit, and 10 minutes after that. RESULTS: The incidence of emergence agitation was 30% in group O and 27.5% in group S at arrival (P = 1.00). Ten minutes after arrival, the incidence was 12.5% in group O and 25% in group S (P = 0.25). CONCLUSIONS: Ondansetron 0.1 mg/kg does not reduce the incidence of emergence agitation after sevoflurane in children.
