Serum serotonin concentration in small breed dogs with degenerative mitral valve disease.
10.12729/jbr.2015.16.4.177
- Author:
Soo Jung LIM
1
;
Sun Hee LEE
;
Kun Ho SONG
Author Information
1. Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea. songkh@cnu.ac.kr
- Publication Type:Brief Communication
- Keywords:
degenerative mitral valve disease;
serotonin;
concentration;
platelet;
dog
- MeSH:
Animals;
Blood Platelets;
Chungcheongnam-do;
Dogs*;
Echocardiography;
Female;
Hospitals, Teaching;
Humans;
Mitral Valve*;
Platelet Count;
Prospective Studies;
Serotonin*
- From:Journal of Biomedical Research
2015;16(4):177-181
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study investigated the potential associations of dog characteristics with serum serotonin (5HT) concentration in dogs with degenerative mitral valve disease (DMVD). Client-owned dogs were prospectively recruited at the Veterinary Medical Teaching Hospital of Chungnam National University between 2010 and 2011. Forty-two dogs (22 females and 20 males) were enrolled in this study. DMVD dogs included Maltese (n=12), followed by Shih-tzu (n=10), mixed breed (n=5), Chihuahua (n=4), Miniature schnauzer (n=3), Miniature poodle (n=3), Miniature pinscher (n=1), Pomeranian (n=1), Yorkshire terrier (n=2), and Spitz (n=1). As inclusion criteria for the study, dogs had to show either direct or echocardiographic evidence of DMVD. Platelet count significantly differed among the three groups, as the moderate (P<0.05) and severe groups (P<0.05) showed significantly higher platelet counts than the mild DMVD group. Additionally, significantly higher LVIDd, LVIDs, fractional shortening (FS), and LA:Ao ratios were observed in dogs with moderate (P<0.05) and severe (P<0.05) DMVD compared to the mild group, respectively. Significant positive correlations between serum 5-hydroxytryptamine (5HT) concentration and platelet count (r=0.273, P=0.03), LA:Ao ratio (r=0.459, P=0.001), and LVIDd (r=0.319, P=0.013) were observed in DMVD dogs. Therefore, serum 5HT concentration may be a potential cause of DMVD progression.
