Influence of Hepatic Damage on the Male Reproductive Glands: IV. Effect of Cortisone on the Reproductive Glands of Male White Rats with Liver Damage.
- Author:
Young Kyoon KIM
1
;
Hak Song LEE
Author Information
1. Department of Urology, Seoul National University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
liver cirrhosis;
cortisone;
male reproductive glan
- MeSH:
Animals;
Carbon Tetrachloride;
Citric Acid;
Cortisone*;
Estrogens;
Humans;
Liver Cirrhosis;
Liver Diseases;
Liver*;
Male*;
Rats*;
Reproduction;
Weights and Measures;
Young Adult
- From:Korean Journal of Urology
1960;1(2):111-117
- CountryRepublic of Korea
- Language:English
-
Abstract:
Young adult male rats were injected with carbon tetrachloride along with cortisone acetate simultaneously and the effect of cortisone acetate on the damage of the liver and the liver's effect on the reproductive gland and its accessories were studied. The following results were obtained: Cortisone acetate given rats with damaged livers caused a very remarkable decrease in the weights of the accessory glands of reproduction, while the liver was restored to normal hepatic architecture. Judging from the marked weight decreases of the glands, cortisone acetate is thought to be responsible for enhancing the estrogenic effect through liver dysfunction despite the return to normal hepatic histology. Citric acid concentration in the prostatic tissue was not altered greatly by cortisone acetate administration. The concentration of the prostatic citrate can not be taken as an index of androgenic activity.
