Polymorphism of Tryptophan Hydroxylase Gene in Alcohol Dependent Patients.
- Author:
Joo Bong HONG
1
;
Sang Ick LEE
;
Chul Jin SHIN
;
Heon KIM
;
Kyung Whan CHI
;
In Won CHUNG
Author Information
1. Department of Neuropsychiatry, College of Medicine, Chungbuk National University, Cheong-ju.
- Publication Type:Original Article
- Keywords:
Alcohol dependence;
Polymorphism;
Tryptophan hydroxylase
- MeSH:
Age of Onset;
Alcoholics;
Alcoholism;
Alleles;
Diagnosis;
Diagnostic and Statistical Manual of Mental Disorders;
Gene Frequency;
Genotype;
Humans;
Male;
Polymerase Chain Reaction;
Polymorphism, Restriction Fragment Length;
Serotonin;
Tryptophan Hydroxylase*;
Tryptophan*
- From:Journal of Korean Neuropsychiatric Association
2001;40(4):718-726
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was performed to explore the association of tryptophan hydroxylase(TPH) gene with diagnosis of alcohol dependence and/or clinical characteristics such as age of onset, family history, and severity of symptoms in Korean alcoholics. METHODS: The genotype and allele frequencies of TPH in 100 male hospitalized patients who met DSM-IV criteria for alcohol dependence were investigated using polymerase chain reaction and restriction fragment length polymorphism and were compared with 100 agematched healthy male control subjects. And the associations between gene polymorphisms and clinical characteristics in alcoholic patients were explored. RESULTS: The distributions of TPH genotype and allele in alcohol dependent patients were not different from control subjects. However, the frequencies of TPH genotype in early-onset alcoholic patients, which were 0.57, 0.39, and 0.04(AA, AC and CC, respectively), were significantly different from those of late-onset alcoholics(0.34, 0.45, and 0.21, respectively). "A" allele was found more frequent in early-onset alcoholics. CONCLUSION: The result suggests that TPH gene polymorphism is associated with early-onset alcoholic patients possibly related with inherited abnormalities of serotonin system.
