Acute generalized exanthematous pustulosis due to hydroxychloroquine in a rheumatoid arthritis patient.
10.4168/aard.2013.1.2.176
- Author:
Hye Jin LIM
1
;
Ji Hye JUNG
;
Min Jeoung KIM
;
Jeoung Min KIM
;
Hye Ran KANG
;
Yoon Kyung SONG
;
Jin Wuk HUR
;
Sang Hoon KIM
;
Eun Kyung KIM
Author Information
1. Department of Internal Medicine, Eulji General Hospital, Seoul, Korea. ksh1134@eulji.ac.kr
- Publication Type:Case Report
- Keywords:
Acute generalized exanthematous pustulosis;
Hydroxychloroquine;
Rheumatoid arthritis
- MeSH:
Acute Generalized Exanthematous Pustulosis;
Arthritis, Rheumatoid;
Biopsy;
Erythema;
Erythrocytes;
Female;
Fever;
Humans;
Hydroxychloroquine;
Leukocytosis;
Neutrophils;
Skin
- From:Allergy, Asthma & Respiratory Disease
2013;1(2):176-178
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute generalized exanthematous pustulosis (AGEP) is characterized by acute nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ), an antimalarial drug, widely used to treat rheumatic and dermatologic diseases. HCQ has been reported to be an uncommon cause of AGEP. We report a 60-year-old woman with rheumatoid arthritis requiring the use of HCQ presented fever and erythematous eruption on the trunk with sterile pustules. Leukocytosis and elevated erythrocyte sedimention rate noted on laboratory examination. On the histopathological examination of the skin biopsy specimen showed neutrophilic infiltration and scattered eosinohpils. The lesions were resolved with removal of HCQ. The clinical course was consistent with the diagnosis of AGEP associated with HCQ. We reported a case of typical AGEP associated with HCQ in a patient with Rheumatoid arthritis. The patient presented resolution from cutaneous lesions with withdrawal of culprit drug, without the need of systemic steroid.
