A Study of Minimal Change in Nocturia Affecting Quality of Life.
10.4111/kju.2009.50.3.241
- Author:
Jong Baek SHIM
1
;
Seong Ho LEE
;
Hayoung KIM
Author Information
1. Department of Urology, School of Medicine, Hallym University, Seoul, Korea. hykim@hallym.or.kr
- Publication Type:Original Article
- Keywords:
Nocturia;
Quality of life
- MeSH:
Deamino Arginine Vasopressin;
Humans;
Nocturia;
Quality of Life
- From:Korean Journal of Urology
2009;50(3):241-245
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: It is well known that nocturia is a bothersome symptom that affects the quality of life (QoL). However, it is not known how much of a decrease in nocturnal frequency is needed to improve the QoL. We determined the minimal change in nocturnal frequency affecting the QoL of patients with nocturia. MATERIALS AND METHODS: A total of 87 patients with BPH and nocturia were treated with alpha-blocker and desmopressin for 8 weeks. Considering that the minimal clinically important change (MCIC) is different according to the baseline value, we divided the patients into two groups (group I, II). Group I had mild to moderate nocturia with voiding <4 times per night, and Group II had severe nocturia with voiding > or =4 times per night. Voiding diaries and King's Health Questionnaires (KHQs) were evaluated before and after treatment. To determine the minimal change in nocturia affecting the QoL, statistical analysis was performed by Student's t-test and ANOVA test with the change in KHQ score according to decreased numbers of nocturnal frequency. RESULTS: Groups I and II had 35 and 52 patients, respectively. The minimal decrease in nocturnal frequency associated with a statistically significant decrease in sleep/energy domain scores was 1 time in Group I and 2 times in Group II. CONCLUSIONS: These data show that decreases in nocturia of at least 1 time in patients with mild to moderate nocturia (<4 times/night) and of 2 times in patients with severe nocturia (> or =4 times/night) are needed to improve the QoL.
