Effects of Metabolic Syndrome on Chronic Kidney Disease.
10.4111/kju.2009.50.3.261
- Author:
In Chang CHO
1
;
Young Won KIM
;
Yunbyung CHAE
;
Tong Wook KIM
;
Seok Joong YUN
;
Sang Cheol LEE
;
Wun Jae KIM
;
Yong June KIM
Author Information
1. Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea. urokyj@cbnu.ac.kr
- Publication Type:Original Article
- Keywords:
Metabolic syndrome;
Obesity;
Chronic renal insufficiency
- MeSH:
Adenosine Triphosphate;
Adult;
Cardiovascular Diseases;
Cholesterol;
Diet;
Glomerular Filtration Rate;
Handling (Psychology);
Humans;
Kidney;
Male;
Multivariate Analysis;
Obesity;
Prevalence;
Renal Insufficiency, Chronic;
Risk Factors;
Stroke
- From:Korean Journal of Urology
2009;50(3):261-266
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Metabolic syndrome (MS) has been identified as a causal risk factor for cardiovascular disease, stroke, and cardiovascular mortality. Recent studies have suggested a possible relation between MS and renal function. The aim of this study was to evaluate the influence of MS on renal function. MATERIALS AND METHODS: We analyzed 12,348 healthy Koreans who underwent a general health checkup. MS was defined as 3 or more of the criteria according to the National Cholesterol Education Program Adult Treatment Panel guidelines III (NCEP ATP III). The glomerular filtration rate (GFR) was estimated by the redefined Modification of Diet in Renal Disease formula. Chronic kidney disease (CKD) was categorized into 3 categories according to the Kidney Disease: Improving Global Outcomes guidelines; I: GFR> or =90 ml/min, II: 60-89 ml/min, III: 30-59 ml/min. RESULTS: The overall proportion with MS was 19.3%. Compared with populations without MS, those with MS showed a significantly decreased GFR. The prevalence of CKD increased with the number of MS components, and it was prominent in the group of males over 40 years of age. In multivariate analyses using age, sex, and individual MS components, age (odds ratio [OR]=20.40; 95% CI: 10.81-38.49), sex (OR=1.98; 95% CI: 1.51-2.60), and obesity (OR=1.48; 95% CI: 1.13-1.93) were strongly associated with CKD. CONCLUSIONS: This study showed that MS is a significant determinant of CKD. Handling of correctable factors such as obesity may be considered one of the preventive modalities against the development of CKD.
