Downregulation of Peroxisome Proliferator-Activated Receptor (PPAR)alpha, PPARgamma, and Phosphoglycerate Mutase 2 in Prostate Cancer.
10.4111/kju.2006.47.6.661
- Author:
Hyuk Jin CHO
1
;
Duk Yoon KIM
;
Jung Wook KIM
;
Tag Keun YOO
;
Eun Kyoung YANG
Author Information
1. Department of Urology, Catholic University of Daegu School of Medicine, Daegu, Korea. dykim@mail.cu.ac.kr
- Publication Type:Original Article
- Keywords:
Prostate cancer;
Peroxisome proliferator-activated receptors;
Phosphoglycerate mutase
- MeSH:
Down-Regulation*;
Glucose;
Metabolism;
Nitrogen;
Peroxisome Proliferator-Activated Receptors;
Peroxisomes*;
Phosphoglycerate Kinase;
Phosphoglycerate Mutase*;
Polymerase Chain Reaction;
PPAR alpha;
PPAR gamma*;
Prostate*;
Prostatectomy;
Prostatic Hyperplasia;
Prostatic Neoplasms*;
RNA;
RNA, Messenger;
Transurethral Resection of Prostate
- From:Korean Journal of Urology
2006;47(6):661-666
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate whether factors related to lipid and glucose metabolism have a potential role in the progression of prostate cancer, we measured the mRNA levels of the peroxisome proliferator-activated receptor (PPAR), fatty acid elongase (ELOVL), and two glycolytic enzymes in prostate cancer (CaP) tissues. MATERIALS AND METHODS: Prostate tissues, obtained from radical prostatectomy (n=10) and transurethral resection of prostate (n=18), were quickly frozen in liquid nitrogen for RNA measurements. Transcript signals of PPAR alpha, PPAR gamma, ELOVL2, ELOVL5, phosphoglycerate kinase 1 (PgK1) and phosphoglycerate mutase 2 (PgM2) were measured using a reverse-transcription polymerase chain reaction. RESULTS: The transcript signals of PPAR alpha and PPAR gamma were down-regulated in CaP tissues. In addition, the mRNA level of PgM2 in CaP tissues was lower than that in benign prostatic hyperplasia (BPH) tissues. However, the messages for ELOVL2, ELOVL5, and PgK1 were not significantly changed. CONCLUSIONS: These results suggest that lowering of the PPARalpha, PPARgamma and PgM2 messages may be involved in aberrant and uncontrolled prostate cell growth and differentiation.
