Retinopathy of Prematurity among Very-Low-Birth-Weight Infants in Korea: Incidence, Treatment, and Risk Factors.
10.3346/jkms.2015.30.S1.S88
- Author:
Jong Hee HWANG
1
;
Eun Hee LEE
;
Ellen Ai Rhan KIM
Author Information
1. Department of Pediatrics, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Retinopathy of Prematurity;
Infant;
Very-Low-Birth-Weight
- MeSH:
Antibodies/therapeutic use;
Birth Weight;
Female;
Gestational Age;
Humans;
Incidence;
Infant;
Infant Mortality;
Infant, Newborn;
Infant, Premature;
*Infant, Very Low Birth Weight;
Logistic Models;
Male;
Odds Ratio;
Prevalence;
Republic of Korea/epidemiology;
Retinopathy of Prematurity/drug therapy/*epidemiology/mortality;
Retrospective Studies;
Risk Factors;
Vascular Endothelial Growth Factor A/immunology
- From:Journal of Korean Medical Science
2015;30(Suppl 1):S88-S94
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was conducted to describe the incidence, risk factors, and current treatment status of retinopathy of prematurity (ROP) in very-low-birth-weight (VLBW) infants registered in the Korean Neonatal Network database. Medical records of 2,009 VLBW infants born between January 2013 and June 2014 who underwent examination by an ophthalmologist were reviewed. The total incidence of ROP was 34.1%. Of the patients, 11.6% showed ROP stage > or = 3 and 11.5% received treatment of VLBW. Among all infants who received treatment of ROP, 63.6% underwent operation only; 16.9%, anti-vascular endothelial growth factor (anti-VEGF) treatment only; and 19.5%, both operation and anti-VEGF treatment. The mean gestational age (GA) and birth weight (BW) were significantly lower and the prevalence rates of respiratory distress syndrome, patent ductus arteriosus (PDA), invasive ventilator duration, and sepsis were significantly higher in the VLBW infants with ROP than in those without ROP. In the multivariable logistic regression analysis, PDA (odd ratio [OR], 2.1; 95% confidence interval [CI], 1.11-3.79) and invasive ventilator duration (OR, 1.0; 95% CI, 1.00-1.02) were significant risk factors of ROP and ROP stage > or = 3. In conclusion, the high incidence of ROP is associated with low GA and BW, and attempt to reduce the aforementioned risk factors could reduce the incidence of ROP stage > or = 3 in VLBW infants.
