The Effect of Additional Factor XIII on Cross-linking in Fibrin Glue.
- Author:
Hyun Sook CHI
;
Seog Woon KWON
;
Dung Won HUH
;
Eul Du SEO
- Publication Type:Original Article
- MeSH:
Factor XIII*;
Fibrin Tissue Adhesive*;
Fibrin*;
Fibrinogen;
Humans;
Plasma
- From:Korean Journal of Blood Transfusion
1994;5(2):137-142
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To investigate the effect of additional factor XIII on the rate of cross-linked fibrin formation in fibrin glue, we prepared concentrated fibrinogen as a source of fibrin glue using thaw -syphon method from fresh frozen plasma, purified human factor XIII from plasma, and performed biochemical analysis of the fibrin glue formed with or without additional factor XIII. It was concluded that additional factor XIII promoted rapid formation of cross-linked fibrin (gamma-gamma dimer and a-polymer) which would be essential to clinically effective fibrin glue.
