Effect of Clonidine Pretreatment on the Cardiovascular Toxicity Induced by Inrravenous Bupivacaine in Rabbits.
10.4097/kjae.1994.27.11.1532
- Author:
Jeong Koo SEO
1
;
Dong Ok KIM
;
Kwang Il SHIN
Author Information
1. Department of Anesthesiology, College of Medicine, Cheongju Hospital, Cheongju, Korea.
- Publication Type:Original Article
- Keywords:
Clonidine pretreatment;
Cardiovascular toxicity;
Bupivacaine
- MeSH:
Arterial Pressure;
Bupivacaine*;
Clonidine*;
Electrocardiography;
Heart Rate;
Humans;
Hypotension;
Infusions, Intravenous;
Male;
Rabbits*;
Systole
- From:Korean Journal of Anesthesiology
1994;27(11):1532-1540
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was performed to evaluate the influence of clonidine pretreatment on the car- diovascular toxic effects of bupivacaine overdose induced by constant intravenous infusion. Thirty male rabbits were used for this study and they were divided into saline pretreatment group(15) and clonidine-pretreatment group(15). The changes of mean arterial pressure, heart rate and electrocardiogram by the bupivacaine-induced toxic effect during intravenous infusion of bupivacaine were observed. The results were as follows; 1. Mean arterial pressure was significantly decreased in clonidine-premedicated group compared with control group (P<0.01) before infusion of bupivacaine, but the times occuring 25% and 50% decrease of mean arterial pressure were significantly prolonged in clonidine group compared with control group (P <0.001 ). 2. Heart rate was significantly decreased in clonidine group compared with control group (P<0.01) before infusion of bupivacaine, but the times occuring 25% and 50% decrease of heart rate were significantly prolonged in clonidine group compared with control group (P< 0.001). 3. The times occuring the first QRS modification and first dysrhythmia and the final systole were significantly prolonged in clonidine group compared with control group (P < 0.001). In conclusion, clonidine given prophylactically delays the cardiotoxicity caused by bupivacaine overdose snd does not accentuate the subsequent hypotension.
