A comparison of the suppression of cough reflex by intravenous lidocaine and remifentanil prior to extubation of the endotracheal tube.
10.4097/kjae.2008.55.4.452
- Author:
Dong Hwa KANG
1
;
Young Whan KIM
;
Suk Whan CHOI
;
Sang Eun LEE
;
Se Hun LIM
;
Jeong Han LEE
;
Kun Moo LEE
;
Soon Ho CHEONG
;
Young Kyun CHOE
;
Young Jae KIM
;
Chee Mahn SHIN
Author Information
1. Department of Anesthesiology and Pain Medicine, College of Medicine, Inje University, Busan, Korea. anehero@naver.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
cough relex;
extubation;
lidocaine;
remifentanil
- MeSH:
Adult;
Breath Holding;
Cough;
Eye;
Humans;
Lidocaine;
Pharyngitis;
Piperidines;
Reflex
- From:Korean Journal of Anesthesiology
2008;55(4):452-457
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cough reflex in response to extubation of the endotracheal tube is common; however, the effect of remifentanil on cough reflex is uncertain. Therefore, we evaluated the effect of lidocaine and remifentanil on cough reflex following extubation. METHODS: Forty adult patients scheduled to undergo elective surgery in two hours were enrolled in this study. All patients received a standard anesthetic protocol. Following surgery, the patients were randomly divided into two groups, Group L (n = 20), which received 1.5 mg/kg of 2% lidocaine intravenously, and Group R (n = 20), which received 0.5 microgram/kg remifentanil intravenously. Treatment was administered immediately after the patients opened their eyes, after which extubation was performed. We then evaluated breath holding and recorded the number of coughs at 5 minutes, 15 minutes and 30 minutes after extubation. In addition, we checked for sore throat 30 minutes after extubation. RESULTS: The number of coughs was significantly lower in Group R than in Group L at 5 minutes after extubation. However, there was no significant difference in the number of coughs in Group R and Group L at any other times evaluated. CONCLUSIONS: There are no significant differences in suppression of the cough reflex in response to treatment with lidocaine and remifentanil.
