A Clinical Study of Hypotensive Effect of Tripamide(Normonal(R)) in Essential Hypertension.
10.4070/kcj.1984.14.1.157
- Author:
Chang Soo LEE
;
Young Gun YOON
;
Jeong Gwan CHO
;
Jung Chaee KANG
;
Ock Kyu PARK
- Publication Type:Original Article
- MeSH:
Aspartate Aminotransferases;
Blood Pressure;
Cholesterol;
Creatinine;
Hypertension*
- From:Korean Circulation Journal
1984;14(1):157-163
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The hypotensive effect of tripamide(Normonal(R)) were evaluated in 31 cases of essential hypertension. Fifteen to thirty mg of tripamide per day were administered continuously for 8 weeks. The results were as follows; 1) The systolic blood pressure was significantly lowered from 175+/-15 mmHg(Mean+/-SD) before treatment to 144+/-17 mmHg after treatment(p<0.01), and the diastolic blood pressure was significantly lowered from 106+/-11 mmHg before treatment to 90+/-12 mmHg after treatment(p<0.01). 2) The systolic blood pressure was lowered 20 mmHg or more in 25 out of 31 cases(80.7%), and the diastolic blood pressure was decreased 10 mmHg or more in 25 out of 31 cases(80.7%) at the end of 8 weeks treatement. 3) There was no significantl differences in the level of SGOT, serum cholesterol, serum electrolytes(Na+, K+, Cl-), BUN, creatinine and urinc acid before and after treatment with tripamide. 4) In most cases the subjective symptoms disappeared or became easier after tripamide treatment. 5) Profound weakness was developed in 2 cases during tripamide administration.
