Four months of magnetized water supplementation improves glycemic control, antioxidant status, and cellualr DNA damage in db/db mice.
10.4163/jnh.2016.49.6.401
- Author:
Hye Jin LEE
1
;
Myung Hee KANG
Author Information
1. Department of Food & Nutrition, Daedeok Valley Campus, Hannam University, 1646 Yuseongdaero, Yuseong-ku, Daejeon 34124, Korea. mhkang@hnu.kr
- Publication Type:Original Article
- Keywords:
diabetic mice;
magnetized water;
glycemic control;
HbA1c;
insulin
- MeSH:
Animals;
Blood Glucose;
DNA Damage*;
DNA*;
Glucose;
Glucose Tolerance Test;
Heart;
Homeostasis;
Insulin;
Mice*;
Plasma;
Punctures;
Tail;
Therapeutic Uses;
Veins;
Water*
- From:Journal of Nutrition and Health
2016;49(6):401-410
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Water is magnetically charged upon contact with a magnet. Although magnetic water products have been promoted since the 1930's, they have not received wide acceptance since their effectiveness is still in question; however, some have reported their therapeutic effects on the body, especially the digestive, nervous, and urinary systems. METHODS: In this study, the effect of magnetized water on glycemic control of 14 diabetic mice (CB57BK/KsJ-db/db) in comparison with 10 control mice (CB57BK/KsJ-db/+(db/+)) was investigated. Seven diabetic control (DMC) mice and seven diabetic mice + magnetized water (DM+MW) were kept for 16 weeks, followed by intraperitoneal glucose tolerance test (IPGTT). Weekly blood glucose was measured from tail veins. Blood obtained from heart puncture was used for HbA1c analysis. RESULTS: Blood glucose level showed a significant difference starting from the 10th week of study (496.1 ± 10.2 mg/dl in DMC vs. 437.9 ± 76.9 mg/dl in DM+MW). Blood glucose followed by IPGTT showed no significant difference between groups at 0, 30, 60, 90, and 120 min, although glucose level at 180 min was significantly reduced in DM+MW mice. Plasma insulin level in DM+MW groups was only 39.5% of that of DMC groups (5.97 ± 1.69 ng/ml in DMC vs. 2.36 ± 0.94 ng/ml in DM+MW). Levels of HbA1c were 12.4% and 9.7% in DMC and DM+MW groups, respectively. CONCLUSION: These results show the promising therapeutic effect of magnetized water in regulating blood glucose homeostasis; however, long-term supplementation or mechanistic study is necessary.
