Hematological Parameters Predicting Complications of Caustic Ingestion: A Retrospective Study.
- Author:
Jun Hyung KIM
1
;
Joon Min PARK
;
Min Joung KIM
;
Kyung Hwan KIM
;
Jun Seok PARK
;
Dong Wun SHIN
;
Hoon KIM
;
Woo Chan JEON
;
Hyun Jong KIM
Author Information
1. Department of Emergency Medicine, Inje University Ilsan Paik Hospital, Gyeonggido, Korea. aero7@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Blood cell count;
Caustics;
Esophagus;
Wounds and injuries
- MeSH:
Alkalies;
Blood Cell Count;
Burns, Chemical;
Caustics;
Eating*;
Edema;
Emergency Service, Hospital;
Esophageal Perforation;
Esophageal Stenosis;
Esophagus;
Humans;
Leukocyte Count;
Leukocytes;
Lymphocytes;
Monocytes;
Neutrophils;
Oxidative Stress;
Prognosis;
Retrospective Studies*;
ROC Curve;
Wounds and Injuries
- From:Journal of the Korean Society of Emergency Medicine
2015;26(6):591-597
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: In addition to chemical burn of the alimentary tract, caustic ingestion can cause severe complications including esophageal perforation, airway edema, esophageal stricture, and death. Hematological parameters have been reported to be useful inflammatory markers predicting prognoses in various clinical situations where oxidative stress is increased. We hypothesized that hematological parameters might be useful for prediction of complications after caustic ingestion. METHODS: We performed a retrospective analysis of patients admitted to our Emergency Department after caustic ingestion. The numbers of leukocytes, neutrophils, lymphocytes, and monocytes, and the neutrophil-lymphocyte ratio were compared between uncomplicated and complicated patient groups. Receiver operating characteristic curve analysis was performed for parameters that differed between the two groups. Subgroup analysis was performed according to the substance ingested, thus acid or alkali. RESULTS: Thirty-seven patients were included in our study and eight had complications. Leukocyte, neutrophil counts, and the neutrophil-lymphocyte ratio of the complicated group were higher than those of the uncomplicated group. The areas under the receiver operating characteristic curves of leukocyte counts, neutrophil counts, and the neutrophil- lymphocyte ratio, were 0.819, 0.832, and 0.750, respectively. The cut-off values of these parameters for prediction of complications were 12 060/uL, 9607/uL, and 2.72, respectively. In subgroup analysis, the leukocyte and neutrophil counts, and the neutrophil-lymphocyte ratio of complicated patients who had ingested alkali were higher than those of the uncomplicated group. CONCLUSION: Leukocyte counts, neutrophil counts, and the neutrophil-lymphocyte ratio might serve as useful predictors of complications after ingestion of caustic substances.
