No Evidence of Association of Interleukin 1A(-889) Genetic Polymorphism with Alzheimer's Disease in Koreans.
- Author:
Jin Hyeong JHOO
1
;
Woong Yang PARK
;
Ki Woong KIM
;
Kwang Hyuk LEE
;
Dong Young LEE
;
Jong Chul YOUN
;
Young Ju SUH
;
Jeong Sun SEO
;
Jong Inn WOO
Author Information
1. Department of Psychiatry, Pundang Jesaeng Hospital,Daejin Medical Center, Seongnam, Kyunggi, Korea.
- Publication Type:Original Article
- Keywords:
Alzheimer's disease(AD);
Interleukin-1A(IL-1A);
Koreans;
association
- MeSH:
Alleles;
Alzheimer Disease*;
Apolipoproteins E;
Asian Continental Ancestry Group;
Genotype;
Humans;
Interleukins*;
Polymorphism, Genetic*
- From:Genomics & Informatics
2004;2(2):81-85
- CountryRepublic of Korea
- Language:English
-
Abstract:
To examine whether the IL-1A(-889) polymorphism associates with a risk for Alzheimer's disease(AD) and acts interactively with the apolipoprotein(APOE) epsilon 4 in the development of AD, we performed genotype analyses of the IL-1A and the APOE of the 102 Korean AD patients and 200 Korean non-demented controls. We failed to detect a significant difference in genotypic and allelic frequencies of IL-1A between the AD group and control group. No overexpression of the IL-1A C/T genotype and IL-1A T allele was found when we analyzed the late-onset and early-onset patients, separately. There was no significant genetic interaction between IL-1A polymorphism and the APOE polymorphism. In conclusion, the IL-1A polymorphism did not contribute to the development of AD independently or interactively with the APOE epsilon4 allele in Koreans.
