Prediction of Motor Recovery Using Diffusion Tensor Tractography in Supratentorial Stroke Patients With Severe Motor Involvement.
10.5535/arm.2015.39.4.570
- Author:
Kang Hee KIM
1
;
Yun Hee KIM
;
Min Su KIM
;
Chang Hyun PARK
;
Ahee LEE
;
Won Hyuk CHANG
Author Information
1. Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wh.chang@samsung.com
- Publication Type:Original Article
- Keywords:
Motor recovery;
Corticospinal tract;
Diffusion tensor tractography;
Fractional anisotropy;
FACT algorithm
- MeSH:
Anisotropy;
Classification;
Diffusion Tensor Imaging;
Diffusion*;
Humans;
Medical Records;
Neuroimaging;
Pyramidal Tracts;
Retrospective Studies;
Stroke*;
Upper Extremity
- From:Annals of Rehabilitation Medicine
2015;39(4):570-576
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate whether early stage diffusion tensor tractography (DTT) values predict motor function at 3 months after onset in supratentorial stroke patients with severe motor involvement. METHODS: A retrospective study design was used to analyze medical records and neuroimaging data of 49 supratentorial stroke patients with severe motor involvement. Diffusion tensor imaging was assessed within 3 weeks after stroke in all patients. Three-dimensional tractography of the ipsilateral corticospinal tract (CST) was performed using the fiber assignment of the continuous tracking algorithm. The two-step DTT analysis was used. The first step was classification according to ipsilateral CST visualization. The second step was a quantitative analysis of the visible-CST group parameters. Motor function was assessed at 2 weeks and at 3 months after stroke. Comparative and correlation analyses were performed between DTT-derived measures and motor assessment scores. RESULTS: Motor function of the upper extremity at 3 months after stroke was significantly higher in the visible-CST group than that in the nonvisible-CST group (p<0.05). Early stage fractional anisotropy was of DTT correlated significantly with upper extremity motor function at 3 months after stroke in the visible-CST group (p<0.05). CONCLUSION: These results demonstrate that early DTT-derived measures predict motor recovery in the upper extremity at 3 months after onset in supratentorial stroke patients with severe motor involvement.
