Validity of 38 mg Low Dose 13C-Urea Breath Test for the Diagnosis of Helicobacter pylori Infection.
- Author:
Yong Jin LEE
1
;
Eun Chul JANG
;
Yong Jin CHO
;
Jung Eun OH
;
Yong Bae KIM
;
Hae Seon NAM
Author Information
1. Department of Occupational Medicine, College of Medicine, Soonchunhyang University, Cheonan, Korea.
- Publication Type:Original Article
- Keywords:
H. pylori infection;
38 mg low dose 13C-urea breath test;
validity
- MeSH:
Breath Tests;
Eating;
Health Promotion;
Helicobacter;
Helicobacter pylori;
ROC Curve;
Sensitivity and Specificity;
Urea
- From:Journal of the Korean Academy of Family Medicine
2008;29(10):788-794
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: To assess the diagnostic value of 13C-UBT using capsulated 38 mg low dose for H. pylori infection, we investigated the sensitivity and specificity of 13C-UBT and to suggest the optimal positive cut-off value of DOB20 in 13C-UBT using ROC analysis. METHODS: The study subjects were 76 healthy individuals (males; 52, females; 24) who visited a health promotion center at a university hospital between July 2005 and June 2007. We tested for H. pylori infection by 38 mg low dose 13C-UBT and histology. We measured the expiratory 13C-urea concentration of basal and 20 minutes value after oral ingestion of 38 mg 13C- labelled urea with capsulated. The breath samples were analysed by gas chromatograph isotope ratio mass spectrometer and expressed as units of delta. RESULTS: Fifty subjects (65.8%) were H. pylori positive as judged from histology. ROC analysis showed an area under the curve (AUC) of 0.943 (95% confidence interval: 0.891~0.995), indicating an excellent classification performance of the model. The sensitivity of 96%, specificity of 85% were achieved at the optimal cut-off value of DOB20 which was 1.39. The 38 mg low dose 13C-UBT was a non-invasive, simple, short-time required and highly accurate method. CONCLUSION: The results suggested that capsulated 38 mg low dose 13C-UBT is considered more in term of accuracy, costeffectiveness and convenient method for the diagnosis of H. pylori infection. Further long-term research and meta analysis based on large-scale investigations is needed to establish a standardized testing method in creating protocol of 13C-UBT.
