Etiopathology of Behcet's disease: herpes simplex virus infection and animal model.
10.3349/ymj.1997.38.6.359
- Author:
Seonghyang SOHN
1
Author Information
1. Laboratory of Cell Biology, Ajou University Institute for Medical Sciences, Suwon, Korea. sohnsh@madang.ajou.ac.kr
- Publication Type:Review ; Research Support, Non-U.S. Gov't
- Keywords:
Behcet's disease;
etiology;
herpes simplex virus;
animal model
- MeSH:
Amino Acid Sequence;
Animal;
Behcet's Syndrome/etiology*;
Disease Models, Animal*;
Herpes Simplex/complications*;
Human;
Mice;
Molecular Sequence Data;
Rabbits
- From:Yonsei Medical Journal
1997;38(6):359-364
- CountryRepublic of Korea
- Language:English
-
Abstract:
The etiology of Behcet's disease has been proposed as being a viral, bacterial, genetic and immunological disorder. After Hulusi Behcet's viral etiological hypothesis, many investigators have tried to confirm this. Scrapings and fluids from patients were applied to subculture in chorioallantoic membranes of fertilized eggs as well as in mice and rabbits by direct intracerebral injection. Since the 1980s, in situ hybridization, blotting, and polymerase chain reaction has also been applied to identify the herpes simplex virus DNA and RNA in patients. Animal models were developed based on environmental pollutants, bacterial and human heat shock protein derived peptides and virus injection. Using these animal models separately and/or concurrently, allows for a more effective investigation into Behcet's disease.
