Retrospective Multicenter Study of Respiratory Syncytial Virus Prophylaxis in Korean Children with Congenital Heart Diseases.
10.4070/kcj.2016.46.5.719
- Author:
Ah Young KIM
1
;
Se Yong JUNG
;
Jae Young CHOI
;
Gi Beom KIM
;
Young Hwue KIM
;
Woo Sup SHIM
;
I Seok KANG
;
Jo Won JUNG
Author Information
1. Yonsei University Severance Cardiovascular, Seoul, Korea. jwjung@yuhs.ac
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Respiratory syncytial virus;
Congenital heart disease;
Pediatrics;
Palivizumab;
Prophylaxis
- MeSH:
Bronchiolitis;
Cardiomyopathies;
Cardiomyopathy, Hypertrophic;
Child*;
Heart Defects, Congenital;
Heart Diseases*;
Heart*;
Hemodynamics;
Humans;
Infant;
Korea;
Palivizumab;
Pediatrics;
Recurrence;
Respiratory Syncytial Viruses*;
Retrospective Studies*;
Seasons;
Tetralogy of Fallot
- From:Korean Circulation Journal
2016;46(5):719-726
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: We conducted a review of current data on respiratory syncytial virus (RSV) prophylaxis with palivizumab, in Korean children with congenital heart diseases (CHD). In 2009, the Korean guideline for RSV prophylaxis had established up to five shots monthly per RSV season, only for children <1 year of age with hemodynamic significance CHD (HS-CHD). SUBJECTS AND METHODS: During the RSV seasons in 2009-2015, we performed a retrospective review of data for 466 infants with CHD, examined at six centers in Korea. RESULTS: Infants received an average of 3.7±1.9 (range, 1-10) injections during the RSV season. Fifty-seven HS-CHD patients (12.2%) were hospitalized with breakthrough RSV bronchiolitis, with a recurrence in three patients, one year after the initial check-up. Among patients with simple CHD, only five (1.1%) patients received one additional dose postoperatively, as per the limitations set by the Korean guideline. Among the 30 deaths (6.4%), five (1.1%) were attributed to RSV infection; three to simple CHD, one to Tetralogy of Fallot, and one to hypertrophic cardiomyopathy (HCM). Of the three HCM patients that exceeded guidelines for RSV prophylaxis, two (66.6%) were hospitalized, and one died of RSV infection (33.3%). CONCLUSION: In accordance to the Korean guideline, minimal injections of palivizumab were administered to patients having HS-CHD
